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SMS 201-995

Octreotide

CAS: 79517-01-4

Molecular Formula: C51H70N10O12S2

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SMS 201-995 - Names and Identifiers

Name Octreotide
Synonyms CCRIS 8708
OCTREOTIDE
Octreotide
SMS 201-995
SMS-201-995
SANDOSTATIN
Sandostatin
UNII-75R0U2568I
Sandostatin LAR
(preservative free)
Sandostatin LAR Depot
OCTREOTIDE (SMS 201-995), ACETATE
cyclic(2-7)-disulfide,(r-l-threonyl-n-(2-hydroxy-1-(hydroxymethyl)propyl)
Octreotide(D-Phe5,Cys6·11,D-Trp8,L-Threoninol12)-SoMatostatin-14 (5-12), SMS-201-995
D-Phenylalanyl-L-cysteinyl-L-phenylalanyl-D-tryptophyl-L-lysyl-L-threonyl-N-[(1R,2R)-2-hydroxy-1-(hydroxyMethyl)propyl]-
D-Phenylalanyl-L-hemicystyl-L-phenylalanyl-D-tryptophyl-L-lysyl-L-threonyl-L-hemicystyl-L-threoninol cyclic (2-7)-disulfide acetate (salt)
D-Phenylalanyl-L-cysteinyl-L-phenylalanyl-D-tryptophyl-L-lysyl-L-threonyl-N-((1R,2R)-2-hydroxy-1-(hydroxymethyl)propyl)-L-cysteinamide cyclic (2-7)-disulfide acetate (salt)
L-Cysteinamide, D-phenylalanyl-L-cysteinyl-L-phenylalanyl-D-tryptophyl-L-lysyl-L-threonyl-N-(2-hydroxy-1-(hydroxymethyl)propyl)-, cyclic(2-7)-disulfide, (R-(R*,R*))-, acetate (salt)
L-Cysteinamide, D-phenylalanyl-L-cysteinyl-L-phenylalanyl-D-tryptophyl-L-lysyl-L-threonyl-N-(2-hydroxy-1-(hydroxymethyl)propyl)-, cyclic (2-7)-disulfide, (R-(R*,R*))-, acetate (salt)
(4R,7S,10S,13R,16S,19R)-10-(4-aminobutyl)-16-benzyl-7-[(1R)-1-hydroxyethyl]-N-[(1R,2R)-2-hydroxy-1-(hydroxymethyl)propyl]-13-(1H-indol-3-ylmethyl)-6,9,12,15,18-pentaoxo-19-(D-phenylalanylamino)-1,2-dithia-5,8,11,14,17-pentaazacycloicosane-4-carboxamide acetate (salt)
CAS 79517-01-4
EINECS 616-695-4
InChI InChI=1/C49H66N10O10S2/c1-28(61)39(25-60)56-48(68)41-27-71-70-26-40(57-43(63)34(51)21-30-13-5-3-6-14-30)47(67)54-37(22-31-15-7-4-8-16-31)45(65)55-38(23-32-24-52-35-18-10-9-17-33(32)35)46(66)53-36(19-11-12-20-50)44(64)59-42(29(2)62)49(69)58-41/h3-10,13-18,24,28-29,34,36-42,52,60-62H,11-12,19-23,25-27,50-51H2,1-2H3,(H,53,66)(H,54,67)(H,55,65)(H,56,68)(H,57,63)(H,58,69)(H,59,64)/t28-,29?,34-,36+,37+,38-,39-,40+,41+,42+/m1/s1
InChIKey XQEJFZYLWPSJOV-XJQYZYIXSA-N

SMS 201-995 - Physico-chemical Properties

Molecular FormulaC51H70N10O12S2
Molar Mass1079.3
Melting Point153-156°C
Boling Point1447.2°C at 760 mmHg
Specific Rotation(α)D20 -42° (c = 0.5 in 95% acetic acid)
Flash Point829.1°C
Solubility H2O: soluble
Vapor Presure0mmHg at 25°C
Storage ConditionInert atmosphere,Store in freezer, under -20°C
In vivo study Octreotide-treated groups show a significant reduction in the tumor volume when compared with saline group. Octreotide-PPSG (1.4 mg/kg, i.p.) shows greater antitumor effect than Octreotide-soln (100 μg/kg, i.p.). Octreotide-treatments results in significant inhibitory effect on the expression levels of SSTR2 and SSTR5 in primary HCC-bearing rats compared with the saline group. Octreotide-PPSG appears to inhibit the expression of SSTR2 and SSTR5 to a greater extent than that of Octreotide-soln treated group. A test dose of octreotide acetate significantly decreases the serum gastrin level to approximately one third of the baseline in 2 hr and the effect lasted approximately for 6 hr. On day 21, treatment with sustained-release formulation of octreotide acetatea (5 mg intramuscular, q 4 wk) is initiated.

SMS 201-995 - Risk and Safety

WGK Germany3
HS Code2937190000
ToxicityTDLo scu-man: 2587 mg/kg:GIT,LVR LANCAO348,1668,1996

SMS 201-995 - Reference

Reference
Show more
1. Zhang Li, Jiang Cheng, Chen Simin, Yao Ting, Xiang Ningling, Su Mengxiang, Di bin. Determination of plasma protein binding rate of peptide candidates by dextran charcoal adsorption [J]. Journal of China Pharmaceutical University, 2020,51(05):522-529.

SMS 201-995 - Nature

Open Data Verified Data

is so far the only successful application in the treatment of gastrointestinal hormone analogs, is a synthetic octapeptide containing a cyclic structure, part of the amino acid sequence similar to somatostatin, with almost all the biological effects of somatostatin, such as inhibition of a variety of pituitary and gastrointestinal pancreatic hormone release, inhibition of gastric acid, pancreatic juice and bile secretion, inhibition of gastrointestinal motility and secretion, etc., but the half-life of somatostatin 30 times.

Last Update：2024-01-02 23:10:35

SMS 201-995 - Preparation solution concentration reference

 1mg5mg10mg
1 mM0 ml0 ml0 ml
5 mM0 ml0 ml0 ml
10 mM0 ml0 ml0 ml
5 mM0 ml0 ml0 ml
Last Update：2024-01-02 23:10:35

SMS 201-995 - Use

Open Data Verified Data

usage and dosage for the treatment of VIP tumor, carcinoid syndrome and gastrinoma. Insulinoma and glucagonoma, 50 ~ lOOug subcutaneous injection every time, 1~2 times a day, can be maintained by intermittent medication after symptom relief. It can also be used to treat acromegaly caused by growth hormone releasing factor (GHF) tumor. In the treatment of gastrointestinal disease fistula, Diarrhea, cirrhosis of the liver and portal hypertension and esophageal variceal bleeding, gastric ulcer disease bleeding, acute pancreatitis.

Last Update：2022-01-01 11:11:39

SMS 201-995 - Safety

Open Data Verified Data

side effects were Abdominal Pain, abdominal distension, Diarrhea, steatorrhea; Gallstone formation; Glucose tolerance may decrease or worsen in the early stage of treatment, and then improve; No endogenous antibody production in long-term use, there was no obvious rebound or adverse reaction when the drug was stopped and rapidly reduced. The remainder was octreotide acetate.

Last Update：2022-01-01 11:11:39
SMS 201-995
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Shanghai Macklin Biochemical Co., Ltd
Featured ProductsSpot supply
Product Name: Octreotide acetate,SMS 201995 Visit Supplier Webpage Request for quotation
CAS: 79517-01-4
Tel: +86-18821248368
Email: Int06@meryer.com
Mobile: +86-18821248368
QQ: 495145328 Click to send a QQ message
WhatsApp: +86-18821248368
Hebei Mojin Biotechnology Co., Ltd.
Spot supply
Product Name: Octreotide Request for quotation
CAS: 79517-01-4
Tel: 0086 15028179902
Email: sales@hbmojin.com
Mobile: 0086 15028179902
QQ: 2632046152 Click to send a QQ message
Wechat: 0086 15028179902
WhatsApp: 0086 15028179902
SKYRUN INDUSTRIAL CO.,LTD
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Product Name: Octreotide Acetate Visit Supplier Webpage Request for quotation
CAS: 79517-01-4
Tel: +86 0571-86722205
Email: sales@chinaskyrun.com
Mobile: +8618958170122
QQ: 2531159185 Click to send a QQ messageSend QQ message
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MedChemExpress (MCE)
Spot supply
Product Name: Octreotide acetate Visit Supplier Webpage Request for quotation
CAS: 79517-01-4
Tel: 609-228-6898
Email: sales@medchemexpress.com
　　　　 tech@medchemexpress.com
Mobile: 609-228-6898
SHANGHAI ACMEC BIOCHEMICAL TECHNOLOGY CO., LTD.
Spot supply
Product Name: Octreotide Acetate Visit Supplier Webpage Request for quotation
CAS: 79517-01-4
Tel: +86-400-900-4166
Email: product@acmec-e.com
Mobile: +86-18621343501
QQ: 2881950922 Click to send a QQ message
Wechat: 18621343501
WhatsApp: +86-18621343501
Shanghai Yuanye Bio-Technology Co., Ltd.
Spot supply
Product Name: Octreotide Acetate Visit Supplier Webpage Request for quotation
CAS: 79517-01-4
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409 Click to send a QQ message
View History
SMS 201-995
SULFOISOPHTHALIC(5-) ACID, MONOLITHIUM SALT
2-[(4-甲基苯基)氨基]乙酸乙酯
(3R)-3-[[(1,1-二甲基乙基)二甲基硅烷基]氧基]-5-氧代-1-环戊烯-1-庚酸甲酯
BENZOIC ACID, 4-[[[(3-CHLORO-4-ETHOXYBENZOYL)AMINO]THIOXOMETHYL]AMINO]-
L-6-OXO-PIPECOLINIC ACID
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